How to Connect to SQL Server Using Python and PyODBC If you are looking to connect to a SQL Server database using Python, PyODBC is a popular choice that provides a simple and efficient way to interact with SQL databases. In this article, we will guide you through the process of connecting to SQL Server using Python and PyODBC. What is PyODBC? PyODBC is an open-source Python module that allows you to connect to and interact with a variety of databases using the ODBC (Open Database Connectivity) standard.